Hydrochloric Acid → 1-Phenyl-3-chloro-3-cyclohexylpropan-1-one

HRID 1376252Notes

Reaction equation

HRID 1376252 reaction equation
[C:1]1([C:7](=[O:17])[CH2:8][CH:9](O)[CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:18]>>[C:1]1([C:7](=[O:17])[CH2:8][CH:9]([Cl:18])[CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 110752881-Phenyl-3-hydroxy-3-cyclohexylpropan-1-one

Product 1

HCID 100377751-Phenyl-3-chloro-3-cyclohexylpropan-1-oneYield 96%

Procedure

The reaction and post treatment were carried out in the same manner as in Example 10 except that 1-phenyl-3-hydroxy-3-cyclohexylpropan-1-one obtained by the same production process as in Preparation Example 1, was used as the starting material, and hydrochloric acid (180 g) was changed to hydrogen chloride gas (20° C., 12,300 ml, 511 mmol), and the reaction was carried out at −20° C., whereby the desired 1-phenyl-3-chloro-3-cyclohexylpropan-1-one (97.1 g, 407 mmol) was obtained in a yield of 96%.

Workup

  1. customThe reaction and post treatment
  2. customobtained by the same production process as in Preparation Example 1
  3. customwas carried out at −20° C.

Sources & evidence

ORD record
ord-c052af79372e407e871aca501ff7e6ec
Source dataset
uspto-grants-2007_01
Patent number
US07169944B2

Reaction notes

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