反应详情

A mixture of 1,4 dibromobutane (50 ml), methyl 4-hydroxy-benzoate (15.2 g, 0.1 mole), potassi-m carbonate (40 g) in 2-butanone (500 ml) was refiuxed for 24 hours. The mixture was filtered, solvent removed and the residue was chromatographed on silica gel eluted with chloroform/petrol and recrystallised from pentane to give methyl 4-(4-bromobutyloxy)benzoate (19.26 g).

1. filtrationThe mixture was filtered
2. customsolvent removed
3. customthe residue was chromatographed on silica gel
4. washeluted with chloroform/petrol
5. customrecrystallised from pentane