L-Phenylalanine → HCID 22916538, compound

HRID 1376394Notes

Reaction equation

C([NH:4][CH:5](C(OCC)=O)[C:6]([O:8]CC)=[O:7])(=O)C.[O:16]([CH2:23][CH2:24]Cl)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N[C@H](C(O)=O)CC1C=CC=CC=1.N[C@H](C(O)=O)CCCNC(=N)N>>[NH2:4][CH:5]([CH:23]([O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:24])[C:6]([OH:8])=[O:7]

Participants

Reactant 4

HCID 6140L-Phenylalanine

HCID 12156Benzene, (2-chloroethoxy)-

HCID 14041Acetamidomalonic acid diethyl ester

HCID 178418600HCID 178418600, compound3×

Product 1

HCID 22916538HCID 22916538, compound

Procedure

(±)-2-Amino-3-phenoxybutyric acid was prepared from diethyl acetamidomalonate and 2-phenoxyethyl chloride by the procedures described in Example 5 and 6. MS (FAB) m/e 802 (M+H)+. Amino Acid Analysis: Cha (0.95), Gly (0.94), Leu (1.03), Arg (1.03).

Sources & evidence

ORD record: ord-8592feda2f274f5ca2fc0daca1172183
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05663148

Reaction notes

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