Sulfuric Acid → HCID 131720150, compound

HRID 1376423Notes

Reaction equation

HRID 1376423 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7](=[N:33][O:34][CH2:35][CH3:36])[C:8]([NH:10][C@@H:11]2[C:31](=[O:32])[N:13]3[C:14]([C:28]([O-:30])=[O:29])=[C:15]([CH2:18][N+:19]4[N:20]([CH2:25][CH2:26][OH:27])[C:21]([NH2:24])=[CH:22][CH:23]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1.[S:37](=[O:41])(=[O:40])([OH:39])[OH:38]>O>[S:37]([OH:41])([O-:40])(=[O:39])=[O:38].[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7](=[N:33][O:34][CH2:35][CH3:36])[C:8]([NH:10][C@@H:11]2[C:31](=[O:32])[N:13]3[C:14]([C:28]([OH:30])=[O:29])=[C:15]([CH2:18][N+:19]4[N:20]([CH2:25][CH2:26][OH:27])[C:21]([NH2:24])=[CH:22][CH:23]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 131720147HCID 131720147, compound

Product 1

HCID 131720150HCID 131720150, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate (syn isomer) (5 g) in water (50 ml) was added 1M sulfuric acid (8 ml). The solution was lyophilized to give 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate sulfate (syn isomer) (5.2 g).

Sources & evidence

ORD record
ord-5f0593ee729f41779f9e51f12adae6d8
Source dataset
uspto-grants-1997_09
Patent number
US05663163

Reaction notes

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