Boc-L-Valine → Tert-butoxycarbonylalanine

Participants

Reaction Steps

Substantially the same procedure as described above was repeated except that N-t-BOC-L-valine (→P8) was used in place of the L-phenylalanine derivative. When N-CBZ-L-proline was used as starting material the deprotection was done by overnight hydrogenation with H2, 10% Pd/C in EtOH (→P9). In case of N-t-BOC-L-alanine the free amine was obtained after evaporation of the solvents and stirring the residue with saturated NaHCO3 solution (→P10).

Provenance & Evidence