O-Methylhydroxylamine hydrochloride → HCID 136041256, compound

Participants

Reaction Steps

97.5 g (1.2 eq) of methoxyamine hydrochloride are added to a solution of 148.8 g (0.97 mol) of methyl pyrrol-2-ylglyoxylate (prepared by a method similar to that described by B. Lindstrom et al., Acta Chem. Scand. 27 (1973), 7) in 11 of methanol, and the solution is refluxed for 2.5 hours. After evaporation in a rotary evaporator, the residue is taken up in ethyl acetate and the solution is washed with water, dried and evaporated down. 81 g (46%) of the pyrrole remained in the form of an oil.

Provenance & Evidence