O-Methylhydroxylamine hydrochloride → HCID 136041256, compound

HRID 1376514Notes

Reaction equation

HRID 1376514 reaction equation
Cl.[CH3:2][O:3][NH2:4].[NH:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[C:10](=O)[C:11]([O:13][CH3:14])=[O:12]>CO>[CH3:2][O:3][N:4]=[C:10]([C:6]1[NH:5][CH:9]=[CH:8][CH:7]=1)[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 18370696HCID 18370696, compound

Product 1

HCID 136041256HCID 136041256, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

97.5 g (1.2 eq) of methoxyamine hydrochloride are added to a solution of 148.8 g (0.97 mol) of methyl pyrrol-2-ylglyoxylate (prepared by a method similar to that described by B. Lindstrom et al., Acta Chem. Scand. 27 (1973), 7) in 11 of methanol, and the solution is refluxed for 2.5 hours. After evaporation in a rotary evaporator, the residue is taken up in ethyl acetate and the solution is washed with water, dried and evaporated down. 81 g (46%) of the pyrrole remained in the form of an oil.

Workup

  1. customprepared by a method similar to
  2. customAfter evaporation
  3. customin a rotary evaporator
  4. washthe solution is washed with water
  5. customdried
  6. customevaporated down

Sources & evidence

ORD record
ord-2bf6726fb6c541b981b7b1563c9c63c4
Source dataset
uspto-grants-1997_09
Patent number
US05663185

Reaction notes

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