Ammonia → HCID 22916670, compound

HRID 1376595Notes

Reaction equation

HRID 1376595 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]2[C:6]([C:9](=[CH2:15])[C:10](OCC)=[O:11])=[N:7][CH:8]=[C:2]12.[NH3:16]>CO>[S:1]1[CH:5]=[CH:4][N:3]2[C:6]([C:9](=[CH2:15])[C:10]([NH2:16])=[O:11])=[N:7][CH:8]=[C:2]12

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22916715HCID 22916715, compound

Product 1

HCID 22916670HCID 22916670, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.445 g of the ethyl 2-(imidazo[5,1-b]-thiazol-5-yl)acrylate obtained in Preparation 26 in 20 ml of methanol was saturated with ammonia gas with ice-cooling. This was sealed tightly, and stirred at room temperature for 7 days. The reaction solution was concentrated, and then purified by using a Sephadex LH 20 column (500 ml), eluting with a 1:1 mixture of methanol and chloroform to give 0.320 g (yield 83%) of the title compound.

Workup

  1. temperaturecooling
  2. customThis was sealed tightly
  3. concentrationThe reaction solution was concentrated
  4. custompurified
  5. washeluting with a 1:1 mixture of methanol and chloroform

Sources & evidence

ORD record
ord-2982145aedc04c8da6044dfe7cf9ad53
Source dataset
uspto-grants-1997_09
Patent number
US05663162

Reaction notes

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