Ammonia → HCID 22916670, compound

Participants

Reaction Steps

A solution of 0.445 g of the ethyl 2-(imidazo[5,1-b]-thiazol-5-yl)acrylate obtained in Preparation 26 in 20 ml of methanol was saturated with ammonia gas with ice-cooling. This was sealed tightly, and stirred at room temperature for 7 days. The reaction solution was concentrated, and then purified by using a Sephadex LH 20 column (500 ml), eluting with a 1:1 mixture of methanol and chloroform to give 0.320 g (yield 83%) of the title compound.

Provenance & Evidence