HCID 15428311, compound → HCID 15379550, compound

HRID 1376609Notes

Reaction equation

HRID 1376609 reaction equation
[OH:1][CH2:2][C:3]1[N:4]2[CH:10]=[N:9][CH:8]=[C:5]2[S:6][CH:7]=1>ClCCl.[O-2].[O-2].[Mn+4]>[S:6]1[CH:7]=[C:3]([CH:2]=[O:1])[N:4]2[CH:10]=[N:9][CH:8]=[C:5]12

Participants

4

Reactant 1

HCID 15428311HCID 15428311, compound

Product 1

HCID 15379550HCID 15379550, compoundYield 71%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

0.211 g of the 3-hydroxymethylimidazo[5,1-b]thiazole prepared in Preparation 55 was suspended in 20 ml of dichloromethane. To this suspension was added 1.1 g of manganese dioxide, and the mixture was stirred at room temperature for 16 hours. The reaction solution was filtered, and then concentrated to dryness under reduced pressure to give 0.146 g (yield 71%) of the title compound.

Workup

  1. filtrationThe reaction solution was filtered
  2. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-bfa9f92d1c53487eb1d70a1ab74d5c1b
Source dataset
uspto-grants-1997_09
Patent number
US05663162

Reaction notes

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