Methyl iodide → HCID 22916702, compound

HRID 1376615Notes

Reaction equation

HRID 1376615 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:17]I>C(#N)C.[Ag]=O>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][O:16][CH3:17])[N:14]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 22916663165667-51-6

Product 1

HCID 22916702HCID 22916702, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 92152Silver(II) oxideCatalystHCID 6342AcetonitrileSolvent

Procedure

0.412 g of 2-(tert-butoxycarbonylamino)methyl-4-hydroxymethylthiazole was dissolved in 8 ml of acetonitrile. To this solution were added 0.98 g of silver oxide and 0.5 ml of methyl iodide, and the mixture was stirred at room temperature for 6 hours. The reaction solution was filtered, and then concentrated to dryness to give 0.385 g (yield 89%) of the title compound.

Workup

  1. filtrationThe reaction solution was filtered
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-918156f6f4e04b12a1826888030443c0
Source dataset
uspto-grants-1997_09
Patent number
US05663162

Reaction notes

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