HRID1376678

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O

HCID111082

4-tert-Butyl hydrogen N-((phenylmethoxy)carbonyl)-L-aspartate

C16H21NO6

HCID114626

tert-Butyl valinate

C9H19NO2

结构：CC(C)[C@H](NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)CN)C(=O)OC(C)(C)C

HCID15674413

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)C(=O)OC(C)(C)C

HCID70050186

未命名化合物

PROCEDURE

实验过程

A diester such as H-Gly-Asp(OtBu)-Val-OtBu can be prepared by condensing Z-Asp(OtBu)-OH and H-Val-OtBu to give Z-Asp(OtBu)-Val-OtBu, hydrogenolyzing the latter, coupling the resulting H-Asp(OtBu)-Val-OtBu with Z-Gly-OSu to give Z-Gly-Asp(OtBu)-Val-OtBu and hydrogenolyzing the latter.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c2bf62bcd4640fba426c57d9c71f519
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05663297
来源说明: uspto-grants-1997_09

反应 SMILES

NCC(N[C@H](C([NH:17][C@H:18]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH:19]([CH3:21])[CH3:20])=O)CC(=O)OC(C)(C)C)=O.[NH:29]([C:42]([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C@H:30]([C:39]([OH:41])=O)[CH2:31][C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35].N[C@H](C(OC(C)(C)C)=O)C(C)C>>[NH:29]([C:42]([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C@H:30]([C:39]([NH:17][C@H:18]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH:19]([CH3:21])[CH3:20])=[O:41])[CH2:31][C:32](=[O:38])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37]