HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-tert-Butyl hydrogen N-((phenylmethoxy)carbonyl)-L-aspartate → Z-Asp(OtBu)-Val-OtBu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-tert-Butyl hydrogen N-((phenylmethoxy)carbonyl)-L-aspartate | HCID 111082 | — |
| Reactant | tert-Butyl L-valinate | HCID 114626 | — |
| Reactant | HCID 15674413 | HCID 15674413 | — |
| Product | Z-Asp(OtBu)-Val-OtBu | HCID 70050186 | — |
Reaction Steps
A diester such as H-Gly-Asp(OtBu)-Val-OtBu can be prepared by condensing Z-Asp(OtBu)-OH and H-Val-OtBu to give Z-Asp(OtBu)-Val-OtBu, hydrogenolyzing the latter, coupling the resulting H-Asp(OtBu)-Val-OtBu with Z-Gly-OSu to give Z-Gly-Asp(OtBu)-Val-OtBu and hydrogenolyzing the latter.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05663297 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-3c2bf62bcd4640fba426c57d9c71f519 |
| Source note | uspto-grants-1997_09 |