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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1376684Generated: October 25, 2026

N-(tert-Butoxycarbonyl)-4-cyano-L-phenylalanine → Diisopropylether ethyl acetate

https://huagongshe.com/reaction/1376684

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(tert-Butoxycarbonyl)-4-cyano-L-phenylalanineHCID 7020841—
ReactantHCID 15674413HCID 15674413—
ProductDiisopropylether ethyl acetateHCID 2228179666%

Reaction Steps

By coupling rac N-Boc-3-(p-cyanophenyl)alanine (French Published Specification 2593 814) and H-Gly-Asp(OtBu)-Val-OtBu there is obtained [N-Boc-3-(p-cyanophenyl)-DL-alanyl]-Gly-Asp(OtBu)-Val-OtBu, m.p. 140°-145° C. from ethyl acetate/isopropyl ether, yield: 66%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05663297
Source datasetuspto-grants-1997_09
ORD IDord-60701ebac5fd488ab6e9f9299269e1e3
Source noteuspto-grants-1997_09