反应详情

To 5.00 g of 5-bromonicotinic acid, 74 ml of thionyl chloride was added and the mixture was heated at reflux for 6 hours. After the solvent was distilled off under reduced pressure, the crystal was washed with diisopropyl ether and collected by filtration to obtain 4.09 g of the objective compound as colorless crystals.

1. temperaturethe mixture was heated
2. temperatureat reflux for 6 hours
3. distillationAfter the solvent was distilled off under reduced pressure
4. washthe crystal was washed with diisopropyl ether
5. filtrationcollected by filtration