Potassium Carbonate → 4-Acetyl-4-phenylpiperidine

HRID 1376820Notes

Reaction equation

HRID 1376820 reaction equation
Cl.[C:2]([C:5]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+]>O>[C:2]([C:5]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)(=[O:4])[CH3:3]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 27237674-Acetyl-4-phenylpiperidine hydrochloride

Product 1

HCID 1015214-Acetyl-4-phenylpiperidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-Acetyl-4-phenylpiperidine hydrochloride was dissolved in water, the solution was made basic by addition of potassium carbonate, and the mixture was extracted with ethyl acetate. The extracts were dried (Na2SO4) and concentrated to give 4-acetyl-4-phenylpiperidine. To a solution of this compound (2.2 g) in dichloromethane (50 ml) was added di-t butyl dicarbonate (2.8 g). After 15 minutes the solution was washed with water, dried, concentrated and the residue crystallised from petroleum ether to give the title compound, mp 91°-92° C.

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extracts were dried (Na2SO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-4986a72bbfc6478ab6c3d5116670e5b3
Source dataset
uspto-grants-1997_09
Patent number
US05663352

Reaction notes

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