反应详情

温度

-20 °C

4 ml of tert.-butyl dichloroacetate and 2 ml of propanal diluted with 2 ml of tetrahydrofuran were mixed together and cooled to -20° C. 28 ml of 0.9M/l of potassium tert.-butylate in tetrahydrofuran were introduced over 12 minutes and at -20° C. followed by allowing the temperature to rise to 20° C. over 1 hour 20 minutes. 25 ml of ether and 25 ml of water were added, followed by stirring, decanting, and re-extracting with ether. The organic phase was washed with water saturated with sodium chloride, then dried and concentrated to dryness to obtain 4.7 g of 1,1-dimethylethyl 2-chloro-3-ethyloxirane carboxylate.

1. additionwere mixed together
2. customdecanting
3. extractionre-extracting with ether
4. washThe organic phase was washed with water saturated with sodium chloride
5. customdried
6. concentrationconcentrated to dryness