Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | HCID 14489186 | HCID 14489186 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 67707707 | HCID 67707707 | — |
Reaction Steps
1.3 g of (6RS) (7RS) 7-[(1,1-dimethylethyloxy)-carbonylamino]-3-methylthio-8-oxo-4-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylic acid and 13 ml of nitromethane were stirred together cooled to 0° C., and a current of hydrochloric acid gas was passed through it for 15 minutes. 130 ml of ether were added, and after separating and rinsing with ether, 0.74 g of 7-amino-3-methylthio-8-oxo-4-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylic acid hydrochloride were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05663164 |
|---|
| Source dataset | uspto-grants-1997_09 |
|---|
| ORD ID | ord-bd1db675eaef420ea2b82f435a40f1d3 |
|---|
| Source note | uspto-grants-1997_09 |
|---|
