Hydrochloric Acid → HCID 67707707, compound

HRID 1376847Notes

Reaction equation

HRID 1376847 reaction equation
CC(C)(OC([NH:7][CH:8]1[C:15](=[O:16])[N:14]2[CH:9]1[CH2:10][S:11][C:12]([S:20][CH3:21])=[C:13]2[C:17]([OH:19])=[O:18])=O)C.[N+](C)([O-])=O.[ClH:27]>CCOCC>[ClH:27].[NH2:7][CH:8]1[C:15](=[O:16])[N:14]2[CH:9]1[CH2:10][S:11][C:12]([S:20][CH3:21])=[C:13]2[C:17]([OH:19])=[O:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6375NitromethaneHCID 14489186HCID 14489186, compound

Product 1

HCID 67707707HCID 67707707, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

1.3 g of (6RS) (7RS) 7-[(1,1-dimethylethyloxy)-carbonylamino]-3-methylthio-8-oxo-4-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylic acid and 13 ml of nitromethane were stirred together cooled to 0° C., and a current of hydrochloric acid gas was passed through it for 15 minutes. 130 ml of ether were added, and after separating and rinsing with ether, 0.74 g of 7-amino-3-methylthio-8-oxo-4-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylic acid hydrochloride were obtained.

Workup

  1. customafter separating
  2. washrinsing with ether

Sources & evidence

ORD record
ord-bd1db675eaef420ea2b82f435a40f1d3
Source dataset
uspto-grants-1997_09
Patent number
US05663164

Reaction notes

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