Hydrochloric Acid → HCID 54333123, compound

HRID 1376856Notes

Reaction equation

HRID 1376856 reaction equation
[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:32][O:33][CH2:34][C:35]2[CH:36]=[N:37][CH:38]=[CH:39][CH:40]=2)[C:27]([O:29]CC)=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O1CCOCC1.[OH-].[Na+].Cl>O.C(O)C>[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:32][O:33][CH2:34][C:35]2[CH:36]=[N:37][CH:38]=[CH:39][CH:40]=2)[C:27]([OH:29])=[O:28])[N:25]=1)([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 54497936HCID 54497936, compound

Product 1

HCID 54333123HCID 54333123, compoundYield 73.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 7 g of the product of Step A, 35 ml of dioxane, 35 ml of ethanol and 21 ml of aqueous N sodium hydroxide was stirred at 35°-40° C. for one hour and after cooling, the pH was adjusted to 2 by addition of aqueous N hydrochloric acid. 250 ml of water were added and the mixture was vacuum filtered. The product was washed and dried to obtain 4.9 g of 2-(2-tritylamino-thiazol-4-yl)-2-(3-pyridinylmethoxyimino)-acetic acid. mp=192° C.

Workup

  1. temperatureafter cooling
  2. filtrationfiltered
  3. washThe product was washed
  4. customdried

Sources & evidence

ORD record
ord-d46f43d275c24818af45684c5f1cab9f
Source dataset
uspto-grants-1997_09
Patent number
US05663164

Reaction notes

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