4-(2,2,2-Trifluoroethyl)aniline → (5SR,6RS)-8-Benzyl-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

HRID 137687Notes

Reaction equation

HRID 137687 reaction equation
[CH2:1]([O:2][C:4](=[O:5])[C:6]1([CH2:20][CH2:21][O:3][CH3:22])[CH:7]([OH:19])[CH2:8][N:9]([CH2:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[CH2:10][CH2:11]1)[CH3:23].[F:24][C:25]([CH2:26][c:27]1[cH:28][cH:29][c:30]([NH2:33])[cH:31][cH:32]1)([F:34])[F:35]>>[C:4]1(=[O:5])[C:6]2([CH:7]([OH:19])[CH2:8][N:9]([CH2:12][c:13]3[cH:14][cH:15][cH:16][cH:17][cH:18]3)[CH2:10][CH2:11]2)[CH2:20][CH2:21][N:33]1[c:30]1[cH:29][cH:28][c:27]([CH2:26][C:25]([F:24])([F:34])[F:35])[cH:32][cH:31]1

Participants

3

Reactant 2

HCID 148368584-(2,2,2-Trifluoroethyl)anilineHCID 580566191-Benzyl-3-hydroxy-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 58056622(5SR,6RS)-8-Benzyl-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-bf02a88ec60d4754b0247adee2177c56
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…