Methylamine → HCID 22918634, compound

HRID 1376886Notes

Reaction equation

HRID 1376886 reaction equation
[CH2:1]([N:8]1[C:12](Br)=[C:11]([N+:14]([O-:16])=[O:15])[C:10]([Br:17])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][NH2:19]>O>[CH2:1]([N:8]1[C:12]([NH:19][CH3:18])=[C:11]([N+:14]([O-:16])=[O:15])[C:10]([Br:17])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 196972381-Benzyl-3,5-dibromo-4-nitro-1H-pyrazole

Product 1

HCID 22918634HCID 22918634, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.61 g (10 mmoles) of 1-benzyl -3,5-dibromo-4-nitropyrazole are heated in 100 ml of a 35-percent solution of methylamine in water for 4 hours at 60° C. After cooling, the separated precipitate is collected by filtration and recrystallized once from ethanol. 2.7 g (87 percent of theory) of 1-benzyl-3-bromo-5-methylamino-4-nitropyrazole are obtained in the form of colorless crystals with a melting point of 116° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe separated precipitate is collected by filtration
  3. customrecrystallized once from ethanol

Sources & evidence

ORD record
ord-247c1dad6cd749e790798edac8c27bb3
Source dataset
uspto-grants-1997_09
Patent number
US05663366

Reaction notes

Loading…