HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → Di-tert-butyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | Isobutylene | HCID 8255 | — |
| Reactant | N-tert-butyl-2,2,2-trichloroacetamide | HCID 304045 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Cyclohexane | HCID 8078 | — |
| Solvent | Dichloromethane cyclohexane | HCID 21916607 | — |
| Solvent | Phosphoric acid boron trifluoride etherate | HCID 86751212 | — |
| Product | Di-tert-butyl ether | HCID 22541 | — |
Reaction Steps
Benzyl alcohol derivatives E6 dissolved in dichloromethane or chloroform are treated with isobutylene in phosphoric acid-boron trifluoride etherate for about 1 to 3 hours at about -78° C. to -60° C. then 18 hours at room temperature or with tert-butyl-2,2,2-trichloroacetamidate in the presence of a catalytic amount of boron trifluoride etherate in cyclohexane or in a mixture of cyclohexane-dichloromethane at room temperature for about 18-24 hours to produce tert-butyl ether derivatives E7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05663448 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-c509cebbb1cd4e558a7b255e9e074523 |
| Source note | uspto-grants-1997_09 |