反应详情

Benzyl alcohol derivatives E6 dissolved in dichloromethane or chloroform are treated with isobutylene in phosphoric acid-boron trifluoride etherate for about 1 to 3 hours at about -78° C. to -60° C. then 18 hours at room temperature or with tert-butyl-2,2,2-trichloroacetamidate in the presence of a catalytic amount of boron trifluoride etherate in cyclohexane or in a mixture of cyclohexane-dichloromethane at room temperature for about 18-24 hours to produce tert-butyl ether derivatives E7.