Methanol → 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol

関与物質

反応条件

反応手順

250 g of methanol, 4.7 g of potassium hydroxide and 10 g of water were added to 23.0 g of geranylgeranyl stearate (containing 22.08 g of geranylgeranyl stearate and 0.37 g of geranylneryl stearate) obtained as a cake in Example 2. The reaction mixture was stirred at 50° C. for 1 hour and cooled down to room temperature, to which 130 g of hexane was added. The resulting organic phase was separated, and the aqueous phase (lower phase) was washed twice with 120 g of hexane. Thereafter, the hexane washings were combined to the organic phase, followed by washing twice with 100 g of a 50% aqueous methanol. The resultant organic phase was concentrated under reduced pressure to give 12 g of crude geranylgeraniol. This crude product was subjected to simple distillation (137° C., 0.3 mmHg) to give 8.2 g of a main fraction. The results of the analysis of the obtained fraction with gas chromatography revealed that it contained geranylgeraniol with a purity of 98.1% and geranylnerol with a purity of 1.2%.

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