Water → HCID 178447997, compound

Then, 18.2 g (0.07 mol) of the obtained (Z)-1,2-difluoro-1-(trans-4-n-propylcyclohexyl)-2-trimethylsilylethylene was dissolved in 50 ml of acetonitrile, and then 8.12 g (0.14 mol) of potassium fluoride and 3.78 g (0.21 mol) of water were added thereto. The mixture was reacted for one hour at 50° C. The reaction mixture was cooled, and then 200 ml of water was added thereto. The mixture was extracted with methylene chloride. The organic layer was washed with a saturated sodium chloride aqueous solution and dried over CaCl2. After filtration, the solvent and low boiling substances were distilled off, and the residue was further distilled under reduced pressure to obtain 10.5 g (yield: 80%) of (E)-1,2-difluoro-1-(trans-4-n-propylcyclohexyl)ethylene.

1. customThe mixture was reacted for one hour at 50° C
2. temperatureThe reaction mixture was cooled
3. extractionThe mixture was extracted with methylene chloride
4. washThe organic layer was washed with a saturated sodium chloride aqueous solution
5. dry with materialdried over CaCl2
6. filtrationAfter filtration
7. distillationthe solvent and low boiling substances were distilled off
8. distillationthe residue was further distilled under reduced pressure

ORD record

ord-237d0beadd6941d2af0a3b054dacff5b

Source dataset

uspto-grants-1997_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05663463