反应详情

In analogy with Example 1i), 4.5g (10.8 mmol) of 5(S)-[1(S)-(Boc-amino)-2-phenylethyl]-3(R)-[(o-fluorophenyl)methyl]dihydrofuran-2-(3H)-one in 170 ml of dimethoxyethane are hydrolysed with 43.5 ml of a 1M lithium hydroxide solution. The evaporation residue of the reaction mixture is poured onto a mixture of ice, 120 ml of sat. ammonium chloride solution and 240 ml of 10% citric acid solution, and this mixture is then extracted with 3 portions of methylene chloride. The organic phases are washed with water and saline, dried over Na2SO4 and evaporated: tRet (II)=14.5 min.

1. extractionthis mixture is then extracted with 3 portions of methylene chloride
2. washThe organic phases are washed with water and saline
3. dry with materialdried over Na2SO4
4. customevaporated
5. customtRet (II)=14.5 min.