1-Iodopentane → HCID 22913235, compound

HRID 1377379Notes

Reaction equation

HRID 1377379 reaction equation
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]([OH:31])[C:27]([F:30])([F:29])[F:28])=[CH:20][N:19]=3)=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH2:32](I)[CH2:33][CH2:34][CH2:35][CH3:36]>[Ag]=O>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[CH:14][C:15]([C:18]3[N:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]([O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])[C:27]([F:30])([F:28])[F:29])=[CH:20][N:19]=3)=[CH:16][CH:17]=2)=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 123351-IodopentaneHCID 22913400HCID 22913400, compound

Product 1

HCID 22913235HCID 22913235, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 92152Silver(II) oxideCatalyst

Procedure

A mixture of 2-(4'-pentylbiphenyl-4-yl)-5-(2-hydroxy-3,3,3-trifluoropropoxy)-pyrimidine (60 mg), pentyl iodide (30 mg) and silver oxide (40 mg) was stirred overnight, followed by filtering off insoluble substance, concentrating the mother liquid and recrystallizing from ethanol to obtain 2-(4'-pentylbiphenyl-4-yl)-5-(2-pentyloxy-3,3,3-trifluoropropoxy)-pyrimidine (30 mg).

Workup

  1. filtrationby filtering off insoluble substance
  2. concentrationconcentrating the mother liquid
  3. customrecrystallizing from ethanol

Sources & evidence

ORD record
ord-1ef51d9bc89c4c0bb797bc5448b04456
Source dataset
uspto-grants-1997_09
Patent number
US05665270

Reaction notes

Loading…