反应详情

50 ml (0.13 mols) of a THF solution of 2.5M of propylmagnesium bromide was dropped in a mixed solution of 36.9 g (0.1 mol) of 1-chloro-4-(4-(3,5-difluoro-4-difluoromethoxyphenyl)butyl)-1-silacyclohexane and 300 ml of THF. The resultant product was found to be a mixture of trans and cis isomers with respect to the silacyclohexane ring. The product was subjected to ordinary aftertreatments such as removal of solvent and salts, followed by isolation through chromatography to obtain 32.1 g (yield: 85%) of the intended trans isomer product.

1. additiona mixture of trans and cis isomers with respect to the silacyclohexane ring
2. customThe product was subjected to ordinary aftertreatments such as removal of solvent and salts
3. customto obtain 32.1 g (yield: 85%) of the intended trans isomer product