Water → 4-Methyl-2-trifluoroacetyloxazole

HRID 1377553Notes

Reaction equation

HRID 1377553 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3](N1C=CN=C1)=[O:4].[CH3:12][C:13]1[N:14]=[C:15]([Si](C)(C)C)[O:16][CH:17]=1.O>C(OCC)C>[CH3:12][C:13]1[N:14]=[C:15]([C:3](=[O:4])[C:2]([F:11])([F:10])[F:1])[O:16][CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 737671-(Trifluoroacetyl)imidazoleHCID 131590734-Methyl-2-(trimethylsilyl)-1,3-oxazole

Product 1

HCID 189363124-Methyl-2-trifluoroacetyloxazole

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Trifluoroacetylimidazole (10 g) was added to a stirred solution of 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. After 20 hours, water was added. The organic phase was separated, dried and evaporated and the residue was purified by flash chromatography to give the title compound as the corresponding hydrate.

Workup

  1. customThe organic phase was separated
  2. customdried
  3. customevaporated
  4. customthe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-0c8d181e4d924edba3ee1e5515808eb9
Source dataset
uspto-grants-1997_09
Patent number
US05665747

Reaction notes

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