HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Methyl-2-trifluoroacetyloxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(Trifluoroacetyl)imidazole | HCID 73767 | — |
| Reactant | 4-Methyl-2-(trimethylsilyl)-1,3-oxazole | HCID 13159073 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Methyl-2-trifluoroacetyloxazole | HCID 18936312 | — |
Reaction Steps
1-Trifluoroacetylimidazole (10 g) was added to a stirred solution of 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. After 20 hours, water was added. The organic phase was separated, dried and evaporated and the residue was purified by flash chromatography to give the title compound as the corresponding hydrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665747 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-0c8d181e4d924edba3ee1e5515808eb9 |
| Source note | uspto-grants-1997_09 |