Acetyl chloride → HCID 54159639, compound

HRID 1377561Notes

Reaction equation

HRID 1377561 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][C:6]1[N:7]=[C:8]([C:12]([C:18]2[S:19][C:20]([CH3:24])=[C:21]([CH3:23])[N:22]=2)([OH:17])[C:13]([F:16])([F:15])[F:14])[S:9][C:10]=1[CH3:11]>CN(C)C1C=CN=CC=1.ClCCl>[C:1]([O:17][C:12]([C:8]1[S:9][C:10]([CH3:11])=[C:6]([CH3:5])[N:7]=1)([C:18]1[S:19][C:20]([CH3:24])=[C:21]([CH3:23])[N:22]=1)[C:13]([F:15])([F:16])[F:14])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 6367Acetyl chlorideHCID 22106686HCID 22106686, compound

Product 1

HCID 54159639HCID 54159639, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

Acetyl chloride (0.68 ml) was added to a solution of 1,1-bis(4,5-dimethyl-2-thiazolyl)-2,2,2-trifluoroethanol (1.54 g) and 4-dimethylaminopyridine (2 g) in dry dichloromethane (70 ml). The mixture was stirred at room temperature overnight and was then washed with saturated aqueous sodium hydrogen carbonate solution. The organic phase was separated, dried and evaporated and the residue was purified by flash chromatography to give the title compound.

Workup

  1. washwas then washed with saturated aqueous sodium hydrogen carbonate solution
  2. customThe organic phase was separated
  3. customdried
  4. customevaporated
  5. customthe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-a035bf02eb144efe84bb339f5b6c0084
Source dataset
uspto-grants-1997_09
Patent number
US05665747

Reaction notes

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