HCID 22915168, compound → HCID 22915173, compound

HRID 1377594Notes

Reaction equation

HRID 1377594 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:16]2([O:21][CH3:22])[CH2:20][O:19][CH2:18][CH2:17]2)[CH:12]=[C:13]([F:15])[CH:14]=1)C1C=CC=CC=1>C(O)C.[Pd]>[F:15][C:13]1[CH:14]=[C:9]([OH:8])[CH:10]=[C:11]([C:16]2([O:21][CH3:22])[CH2:20][O:19][CH2:18][CH2:17]2)[CH:12]=1

Participants

4

Reactant 1

HCID 22915168HCID 22915168, compound

Product 1

HCID 22915173HCID 22915173, compoundYield 108.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 4-(3-benzyloxy-5-fluorophenyl)-4-methoxytetrahydrofuran (1.1 g) in ethanol (20 ml) was hydrogenated in the presence of 10% palladium-on-charcoal catalyst (1 00 mg) for about 3 hours. The mixture was filtered and the filtrate was evaporated to give 840 mg of the title compound. m.p. 136°-137° C.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-87dfc3ec3e00434e81cc44fe5e04f708
Source dataset
uspto-grants-1997_09
Patent number
US05665749

Reaction notes

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