反应详情

A solution of 2-(S)-(2,2-dimethyl-5-oxo-1.3-dioxolan-4-(R)-yl)-4-methylpentanoic acid (1.1 g, 4.78 mmole), pentafluorophenol (970 mg, 5.27 mmole), and 1-dimethylaminopropyl-3-ethyl carbodiimide methiodide (1.42 g, 4.78 mmole) in CH2Cl2 (25 ml) was stirred at 23° for 24 h. The reaction was washed with H2O, 5% aqueous K2CO3, H2O, dried (K2CO3), and the solvent evaporated, to yield the title compound (1.39 g, 74%).

1. washThe reaction was washed with H2O, 5% aqueous K2CO3, H2O
2. dry with materialdried (K2CO3)
3. customthe solvent evaporated