HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-t-Butyloxycarbonyl-4-((2-carboxymethoxyphenyl)amino)piperidine → 4-(3-Oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-t-Butyloxycarbonyl-4-((2-carboxymethoxyphenyl)amino)piperidine | HCID 22380704 | — |
| Reactant | Edc hobt | HCID 86583742 | — |
| Product | 4-(3-Oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 22380676 | — |
Reaction Steps
1-t-Butyloxycarbonyl-4-((2-carboxymethoxyphenyl)amino)piperidine (5.2 g, 15 mmol) from Step 3 was cyclized using the EDC/HOBT coupling procedure given in Step 5 of Example 1. 4-(1-tert-butyloxycarbonyl-4-piperidinyl)-(2H)-1,4-benzoxazin-3(4H)-one was obtained as a foam (86% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665719 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-dc198efe4a6d42609857a4d46bc344ad |
| Source note | uspto-grants-1997_09 |