Hydrochloric Acid → 2H-1,4-Benzoxazin-3(4H)-one, 4-(4-piperidinyl)-

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	4-(3-Oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester	HCID 22380676	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	2H-1,4-Benzoxazin-3(4H)-one, 4-(4-piperidinyl)-	HCID 22293810	—

Reaction Steps

4-(1-tert-butyloxycarbonyl-4-piperidinyl)-(2H)-1,4-benzoxazin-3(4H)-one from Step 4 was N-deprotedcted with HCl in EtOAc using the procedure given in Step 4 of Example 1. The hydrochloride salt of 4-(4-piperidinyl)-(2H)-1,4-benzoxazin-3(4H)-one was obtained as a solid (95% yield).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05665719
Source dataset	uspto-grants-1997_09
ORD ID	ord-63bc2a7525ec460a945f91c4b6749aa4
Source note	uspto-grants-1997_09