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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1377684Generated: November 1, 2026

Hydrochloric Acid → 3-(4-Piperidinyl)-1,3-benzoxazol-2(3H)-one

https://huagongshe.com/reaction/1377684

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactanttert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylateHCID 22644594—
SolventEthyl AcetateHCID 8857—
Product3-(4-Piperidinyl)-1,3-benzoxazol-2(3H)-oneHCID 11321928—

Reaction Steps

3-(1-t-Butyloxycarbonyl-4-piperidinyl)benzoxazolidin-2-one from Step 1 was N-deprotected with HCl in EtOAc using the procedure given in Step 4 of Example 1. The hydrochloride salt of 3-(4-piperidinyl)benzoxazolidin-2-one was obtained as a solid (96% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05665719
Source datasetuspto-grants-1997_09
ORD IDord-cb330d35d3b840e4bacaa83b96216faa
Source noteuspto-grants-1997_09