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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1377692Generated: October 30, 2026

Methyl 3-amino-2-thiophenecarboxylate → HCID 22914655, compound

https://huagongshe.com/reaction/1377692

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-amino-2-thiophenecarboxylateHCID 89652—
Reactanttert-Butyl 4-oxopiperidine-1-carboxylateHCID 735900—
ReactantSodium cyanoborohydrideHCID 5003444—
ProductHCID 22914655HCID 22914655—

Reaction Steps

3-Amino-2-methoxycarbonylthiophene is reductively alkylated with 1-tert-butyloxycarbonylpiperidin-4-one and sodium cyanoborohydride to give 3-(1-tert-butyloxycarbonylpiperidin-4-ylamino)-2-methoxycarbonylthiophene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05665719
Source datasetuspto-grants-1997_09
ORD IDord-97355b2d62074f299ce28667cf3b0ee4
Source noteuspto-grants-1997_09