Methyl 3-amino-2-thiophenecarboxylate → HCID 22914655, compound

HRID 1377692Notes

Reaction equation

HRID 1377692 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([O:9][CH3:10])=[O:8].[C:11]([O:15][C:16]([N:18]1[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]1)=[O:17])([CH3:14])([CH3:13])[CH3:12].C([BH3-])#N.[Na+]>>[C:11]([O:15][C:16]([N:18]1[CH2:23][CH2:22][CH:21]([NH:1][C:2]2[CH:6]=[CH:5][S:4][C:3]=2[C:7]([O:9][CH3:10])=[O:8])[CH2:20][CH2:19]1)=[O:17])([CH3:14])([CH3:12])[CH3:13]

Participants

4

Reactant 3

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 5003444Sodium cyanoborohydride

Product 1

HCID 22914655HCID 22914655, compound

Procedure

3-Amino-2-methoxycarbonylthiophene is reductively alkylated with 1-tert-butyloxycarbonylpiperidin-4-one and sodium cyanoborohydride to give 3-(1-tert-butyloxycarbonylpiperidin-4-ylamino)-2-methoxycarbonylthiophene.

Sources & evidence

ORD record
ord-97355b2d62074f299ce28667cf3b0ee4
Source dataset
uspto-grants-1997_09
Patent number
US05665719

Reaction notes

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