Borane → HCID 22914735, compound

HRID 1377694Notes

Reaction equation

HRID 1377694 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:19]=[CH:18][S:17][C:16]=2[C:20](O)=[O:21])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].B>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]2[CH:19]=[CH:18][S:17][C:16]=2[CH2:20][OH:21])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6331BoraneHCID 22914670HCID 22914670, compound

Product 1

HCID 22914735HCID 22914735, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from Step 2 is reduced with borane in THF to give 3-(1-tert-butyloxycarbonylpiperidin-4-ylamino)-2-hydroxymethylthiophene.

Sources & evidence

ORD record
ord-d91533f8318b4887862e757c4224aa72
Source dataset
uspto-grants-1997_09
Patent number
US05665719

Reaction notes

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