HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 17876715, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | (2-Aminopyridin-3-yl)methanol | HCID 11159325 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 17876715 | HCID 17876715 | — |
Reaction Steps
The product from Step 1 and 1-(tert-butyloxycarbonyl)piperidin-4-one are heated together in a solvent such as THF or methanol. The cooled mixture is treated with sodium cyanpborohydride to give 1-(tert-butyloxycarbonyl)-4-(3-hydroxymethyl-2-pyridylamino) piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665719 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-01f9000c4b894f87a9635e247a9148fd |
| Source note | uspto-grants-1997_09 |