Ammonia → HCID 22915472, compound

HRID 1377906Notes

Reaction equation

HRID 1377906 reaction equation
C([O:3][C:4](=O)[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)C.C([O:26]C(=O)CCCOC1C=CC=C(C2C=CC=CC=2)C=1)C.[NH3:45]>>[CH3:22][O:21][C:18]1[CH:17]=[CH:16][C:15]([C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][CH2:5][C:4]([NH:45][OH:26])=[O:3])=[CH:10][CH:11]=2)=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 54169979HCID 54169979, compoundHCID 54546501HCID 54546501, compound

Product 1

HCID 22915472HCID 22915472, compound

Procedure

The desired compound was prepared according to the method of Example 2, steps 2 and 3, except substituting 4-[4-(4-methoxyphenyl)phenoxy]butanoic acid ethyl ester, prepared as in step 1, for 4-(3-phenylphenoxy)butanoic acid ethyl ester. 1H NMR (CD3OD) δ 2.08 (dt, 2H, J=6.8, 13.6 Hz), 2.30 (t, 2H, J=7.4 Hz), 3.80 (s, 3H), 4.01 (t, 2H, J=6.0 Hz), 6.94 (d, 4H, J=8.8 Hz),7.46 (d, 2H, J=8.5 Hz), 7.46 (d, 2H, J=8.8 Hz). MS (DCI/NH3) 302 (M+H)+, 319 (M+NH4)+. Anal. Calcd for C17H19NO4 ·0.40H2O·0.60NH4Cl: C, 59.94; H, 6.57; N, 6.58. Found: C, 60.28; H, 6.50; N, 6.60.

Sources & evidence

ORD record
ord-ba7747834f894e95ba330226ec42b78e
Source dataset
uspto-grants-1997_09
Patent number
US05665777

Reaction notes

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