Ammonia → HCID 22915513, compound

HRID 1377921Notes

Reaction equation

HRID 1377921 reaction equation
C([O:8][NH:9][C:10](=[O:28])[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)C1C=CC=CC=1.C(ONC(=O)CCCOC1C=CC=C(C2C=CC(F)=CC=2)C=1)C1C=CC=CC=1.N>>[C:26]([C:23]1[CH:24]=[CH:25][C:20]([C:17]2[CH:18]=[CH:19][C:14]([CH2:13][CH2:12][CH2:11][C:10]([NH:9][OH:8])=[O:28])=[CH:15][CH:16]=2)=[CH:21][CH:22]=1)#[N:27]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 22915441HCID 22915441, compoundHCID 22915464HCID 22915464, compound

Product 1

HCID 22915513HCID 22915513, compound

Procedure

The desired compound was prepared according to the method of Example 15, step 4, except substituting N-benzyloxy-4-[4-(4-cyanophenyl)phenyl]butyramide, prepared as in step 1, for N-benzyloxy-4-[3-(4-fluorophenyl)phenoxyl]butyramide. 1H NMR (DMSO-d6) δ 1.82 (m, 2H), 1.99 (t, 2H, J=8 Hz), 2.62 (t, 2H, J=7 Hz), 7.33 (d, 2H, J=9 Hz), 7.69 (d, 2H, J=9 Hz), 7.89 (m, 4H), 8.68 (s, 1H), 10.38 (s, 1H). MS (DCI/NH3) 298 (M+NH4+, 80), 280 (M+H+, 75), 236 (100).

Sources & evidence

ORD record
ord-05f49fc1d6fc4cf0a1ece0c9b4536285
Source dataset
uspto-grants-1997_09
Patent number
US05665777

Reaction notes

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