4-Toluenesulfonyl chloride → 2-(6-Methylquinolin-2-yl)benzonitrile

HRID 1377967Notes

Reaction equation

HRID 1377967 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([NH2:16])=O)[CH:6]=[CH:5]2.C1(C)C=CC(S(Cl)(=O)=O)=CC=1>O>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]#[N:16])[CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 229156312-(6-Methylquinolin-2-yl)benzamide

Product 1

HCID 218042392-(6-Methylquinolin-2-yl)benzonitrileYield 45%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

15 ml of pyridne were added to 2.05 g (7.82 mmol) of 2-(6-methylquinolin-2-yl)benzamide obtained in Reference Example 7 and the mixture was stirred. Were, 1.49 g (7.82 mmol) of p-toluenesulfonyl chloride were added thereto and stirred at room temperature for 2 hours. After further stirring the mixture at 40° C. for 2 hours, the reaction mixture was poured into 30 ml of water and extracted with 50 ml of methylene chloride. The resulting extract was dried over magnesium sulfate followed by filtration. The filtrate was concentrated and the concentrate was subjected to silica gel chromatography using a mixed solvent of hexane and ethyl acetate (7/1) to obtain 0.86 g of 2-(6-methylquinolin-2-yl)benzonitrile.

Workup

  1. customobtained in Reference Example 7
  2. stirringstirred at room temperature for 2 hours
  3. stirringAfter further stirring the mixture at 40° C. for 2 hours
  4. extractionextracted with 50 ml of methylene chloride
  5. extractionThe resulting extract
  6. dry with materialwas dried over magnesium sulfate
  7. filtrationfollowed by filtration
  8. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-2beebf658ce547bfb9a06a23e8bca160
Source dataset
uspto-grants-1997_09
Patent number
US05665881

Reaction notes

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