Hydrochloric Acid → 3-(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride

HRID 1378069Notes

Reaction equation

HRID 1378069 reaction equation
[CH2:1]([N:3]([CH2:6][C:7]1[O:11][N:10]=[C:9]([C:12]2[N:13]=[CH:14][N:15]3[C:21]4[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:20]=4[C:19](=[O:27])[N:18]([CH3:28])[CH2:17][C:16]=23)[N:8]=1)[CH2:4][CH3:5])[CH3:2].[ClH:29]>C(O)C>[ClH:29].[CH2:1]([N:3]([CH2:6][C:7]1[O:11][N:10]=[C:9]([C:12]2[N:13]=[CH:14][N:15]3[C:21]4[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:20]=4[C:19](=[O:27])[N:18]([CH3:28])[CH2:17][C:16]=23)[N:8]=1)[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22914460HCID 22914460, compound

Product 1

HCID 229144593-(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochlorideYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.30 g (0.0034 mol) of 3-(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo [1,5-a]-[1,4]benzodiazepin-6-one in 20 ml of ethanol were treated with 0.79 ml (0.0037 mol) of 4.78N ethanolic hydrochloric acid. Crystals separated after the addition of 100 ml of ether. There were obtained 1.28 g (90%) of 3-(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6- dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride as white crystals; m.p. 220°-223° (dec.).

Workup

  1. customCrystals separated
  2. additionafter the addition of 100 ml of ether

Sources & evidence

ORD record
ord-5cb6c9d5354a462db16e36fd3fdb210f
Source dataset
uspto-grants-1997_09
Patent number
US05665718

Reaction notes

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