Hydrochloric Acid → HCID 70078313, compound

HRID 1378071Notes

Reaction equation

HRID 1378071 reaction equation
[CH2:1]([N:5]([CH2:10][C:11]1[O:15][N:14]=[C:13]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)[N:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4].[ClH:33]>C(O)C>[ClH:33].[CH2:1]([N:5]([CH2:10][C:11]1[O:15][N:14]=[C:13]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)[N:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22914244HCID 22914244, compound

Product 1

HCID 70078313HCID 70078313, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.17 g (0.0027 mol) of 3-(5-dibutylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 30 ml of ethanol were treated with 0.65 ml (0.0031 mol) of 3.7N ethanolic hydrochloric acid. The solvent was freed completely from solvent and the residue was recrystallized from acetone. There was obtained 0.87 g (69%) of 3-(5-dibutylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6- one hydrochloride as white crystals; m.p. 183°-185°.

Workup

  1. customthe residue was recrystallized from acetone

Sources & evidence

ORD record
ord-4af3fb56cd1a4a168ac5b4986402d656
Source dataset
uspto-grants-1997_09
Patent number
US05665718

Reaction notes

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