Hydrochloric Acid → HCID 22914352, compound

Participants

Reaction Steps

0.094 g (0.21 mmol) of 7-chloro-3-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 10 ml of ethanol was treated with 0.06 ml (0.23 mmol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 30 minutes the solution was completely freed from the solvents, whereupon the residue was suspended in 20 ml of ether and filtered off under suction. There were obtained 0.84 g (83%) of 7-chloro-3-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 152°-154°.

Provenance & Evidence