Hydrochloric Acid → HCID 22914352, compound

HRID 1378090Notes

Reaction equation

HRID 1378090 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][C:18]([CH2:21][N:22]([CH2:26][CH2:27][CH3:28])[CH2:23][CH2:24][CH3:25])=[N:19][N:20]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:31].Cl>C(O)C.CCOCC>[ClH:1].[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][C:18]([CH2:21][N:22]([CH2:26][CH2:27][CH3:28])[CH2:23][CH2:24][CH3:25])=[N:19][N:20]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:31]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22914353HCID 22914353, compound

Product 1

HCID 22914352HCID 22914352, compoundYield 1,655.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

0.094 g (0.21 mmol) of 7-chloro-3-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 10 ml of ethanol was treated with 0.06 ml (0.23 mmol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 30 minutes the solution was completely freed from the solvents, whereupon the residue was suspended in 20 ml of ether and filtered off under suction. There were obtained 0.84 g (83%) of 7-chloro-3-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 152°-154°.

Workup

  1. filtrationfiltered off under suction

Sources & evidence

ORD record
ord-4b040f1634dc487694b3aa96a0b55459
Source dataset
uspto-grants-1997_09
Patent number
US05665718

Reaction notes

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