HRID13782

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(C(=O)Cl)ccc1CN1CCN(C)CC1.Cl.Cl

HCID23073514

未命名化合物

HCID23145966

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cncc(Br)c4)n3)c2)ccc1CN1CCN(C)CC1

HCID11786763

未命名化合物

PROCEDURE

实验过程

This compound was prepared in the same manner as in Example 1, except that 3-[4-(5-bromopyridin-3-yl)pyrimidin-2-ylamino]-4-methylaniline (Reference Example 19) and 3-methoxy-4-(4-methylpiperazin-1-ylmethyl)benzoyl chloride dihydrochloride (Reference Example 3) were used, and that the reaction was conducted at room temperature for 17 hours and the crude product was purified by silica gel column chromatography.

WORKUP

后处理

customthe crude product was purified by silica gel column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a8e5e39d221845f1ad885ba89723a451
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07728131B2
来源说明: uspto-grants-2010_06

反应 SMILES

[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[C:17]([CH:19]=[CH:20][C:21]=3[CH3:22])[NH2:18])[N:9]=2)[CH:5]=[N:6][CH:7]=1.Cl.Cl.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][C:35]=1[CH2:36][N:37]1[CH2:42][CH2:41][N:40]([CH3:43])[CH2:39][CH2:38]1)[C:30](Cl)=[O:31]>>[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][C:35]=1[CH2:36][N:37]1[CH2:42][CH2:41][N:40]([CH3:43])[CH2:39][CH2:38]1)[C:30]([NH:18][C:17]1[CH:19]=[CH:20][C:21]([CH3:22])=[C:15]([NH:14][C:10]2[N:9]=[C:8]([C:4]3[CH:5]=[N:6][CH:7]=[C:2]([Br:1])[CH:3]=3)[CH:13]=[CH:12][N:11]=2)[CH:16]=1)=[O:31]