Hydrochloric Acid → HCID 22914415, compound

HRID 1378217Notes

Reaction equation

HRID 1378217 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[N:20]=[C:19]([CH2:21][N:22]([CH2:26][CH2:27][CH3:28])[CH2:23][CH2:24][CH3:25])[O:18][N:17]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:31].Cl.CCOCC>C(O)C>[ClH:1].[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[N:20]=[C:19]([CH2:21][N:22]([CH2:26][CH2:27][CH3:28])[CH2:23][CH2:24][CH3:25])[O:18][N:17]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[F:31]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 22914416HCID 22914416, compound

Product 1

HCID 22914415HCID 22914415, compoundYield 167%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.25 g (2.8 mmol) of 7-chloro-3-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-yl) -8-fluoro-5-methyl-5,6-dihydro-4H-imidazo [1,5-a][1,4]benzodiazepin-6-one in 20 ml ethanol were treated with 0.84 ml (3.07 mmol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 30 minutes the solution was treated with 100 ml of ether and the white suspension obtained was suction filtered. There were obtained 1.13 g (84%) of 7-chloro-3-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 209°-211° (dec.).

Workup

  1. customthe white suspension obtained
  2. filtrationfiltered

Sources & evidence

ORD record
ord-3839fa0ac819474f9c252ac75ef5f89c
Source dataset
uspto-grants-1997_09
Patent number
US05665718

Reaction notes

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