反应详情

1.25 g (2.8 mmol) of 7-chloro-3-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-yl) -8-fluoro-5-methyl-5,6-dihydro-4H-imidazo [1,5-a][1,4]benzodiazepin-6-one in 20 ml ethanol were treated with 0.84 ml (3.07 mmol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 30 minutes the solution was treated with 100 ml of ether and the white suspension obtained was suction filtered. There were obtained 1.13 g (84%) of 7-chloro-3-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 209°-211° (dec.).

1. customthe white suspension obtained
2. filtrationfiltered